CRYSTAL STRUCTURE OF SHIKIMATE DEHYDROGENASE (AROE) FROM HAEMOPHILUS INFLUENZAE

The crystal structure of shikimate dehydrogenase (AroE) reveals a unique NADPH binding mode

Chirality error at the CB center of MET A 271.

MDLYAVWGNPIAQSKSPLIQNKLAAQTHQTMEYIAKLGDLDAFEQQLLAFFEEGAKGCNITSPFKERAYQLADEYSQRAK
LAEACNTLKKLDDGKLYADNTDGIGLVTDLQRLNWLRPNQHVLILGAGGATKGVLLPLLQAQQNIVLANRTFSKTKELAE
RFQPYGNIQAVSMDSIPLQTYDLVINATSAGLSGGTASVDAEILKLGSAFYDMQYAKGTDTPFIALCKSLGLTNVSDGFG
MLVAQAAHSFHLWRGVMPDFVSVYEQLKKAML

12% PEG 8000, 0.15 M Ca Acetate, 0.1 M Imidazole, pH 7.8, VAPOR DIFFUSION, SITTING DROP, temperature 298.0K

Shikimate Dehydrogenase, Haemophilus influenzae, NADPH, OXIDOREDUCTASE