Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc
MNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTRE AISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDT AEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLR
Free protein structure (residues 111-317)
Protein (residues 127-317) complexed to TrkA phosphopeptide
The structure was determined using triple-resonance NMR spectroscopy.
distance geometry, simulated annealing, molecular dynamics
0.5mM Shc PTB Domain, 50mM Sodium phosphate, 20mM DTT-d10
Free Protein, Structure Disorder, Beta Sandwich, Signaling protein