Crystal structure of the retinoblastoma tumour suppressor protein bound to E2F peptide

Crystal Structure of the Retinoblastoma Tumor Suppressor Protein Bound to E2F and the Molecular Basis of its Regulation

PBR3, PRB-BINDING PROTEIN E2F-1, RETINOBLASTOMA-ASSOCIATED PROTEIN 1

HTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVKDIGYIFKEKFAKAVGQGCVEIGSQRYKLGVR
LYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFYKV
IESFIKAEGNLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESA

FQTQKPLKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVK
NIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPR

MOUSE IMPORTIN ALPHA-BIPARTITE NLS FROM HUMANRETINOBLASTOMA PROTEIN COMPLEX

STRUCTURE OF RB TUMOR SUPPRESSOR BOUND TO THETRANSACTIVATION DOMAIN OF E2F-2

CDK2/CYCLINA IN COMPLEX WITH A 9 RESIDUE RECRUITMENT PEPTIDE FROM E2F

DOMAIN A OF HUMAN RETINOBLASTOMA TUMOR SUPPRESSOR

CDK2/CYCLINA IN COMPLEX WITH AN 11-RESIDUE RECRUITMENT PEPTIDE FROM E2F

RETINOBLASTOMA POCKET COMPLEXED WITH SV40 LARGE T ANTIGEN

STRUCTURE OF THE RB C-TERMINAL DOMAIN BOUND TO AN E2F1-DP1HETERODIMER

RETINOBLASTOMA-ASSOCIATED PROTEIN:
REGULATOR OF OTHER GENES. ACTS AS A TUMOR SUPPRESSOR.
INTERACTS PREFERENTIALLY WITH TRANSCRIPTION FACTOR E2F1

TRANSCRIPTION FACTOR E2F1:
TRANSCRIPTION ACTIVATOR THAT BINDS DNA COOPERATIVELY.
FOUND IN THE PROMOTER REGION OF A NUMBER OF GENES WHOSE
PRODUCTS ARE INVOLVED IN CELL CYCLE REGULATION OR IN
DNA REPLICATION.

APOPTOSIS, TUMOUR SUPPRESSOR, CELL CYCLE REGULATION, DNA-BINDING