Structural analysis of the GAP-related domain from neurofibromin and its implications.

The Ras-Rasgap Complex: Structural Basis for Gtpase Activation and its Loss in Oncogenic Ras Mutants

Confirmation of the Arginine-Finger Hypothesis for the Gap-Stimulated GTP- Hydrolysis Reaction of Ras

Structural Differences in the Minimal Catalytic Domains of the Gtpasse- Activating Proteins P120Gap and Neurofibromin

3-Dimensional Structure of the Gtpase Activating Domain of Human P120Gap and Implications for the Interaction with Ras

Formation of a Transition-State Analog of the Ras Gtpase Reaction by Ras:Gdp, Tetrafluoroaluminate and Gtpase-Activating Proteins

The Neurofibromatosis Type I Gene and its Protein Product

The NF1 Locus Encodes a Protein Functionally Related to Mammalian Gap and Yeast Ira Proteins

The Gap-Related Domain of the Neurofibromatosis Type I Gene Product Interacts with Ras P21

The Catalytic Domain of the Neurofibromatosis Type I Gene Product Stimulates Ras Gtpase and Complements Ira Mutants of S. Cerevisiae

Refined Crystal Structure of the Triphosphate Conformation of H-Ras P21 at 1.35 A Resolution: Implications for the Mechanism of GTP Hydrolysis

ETVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFRG
NSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFEVDPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEF
PPQLRSVCHCLYQVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPIIERGLKLMSKILQSIANHVLFTKE
EHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDK
MATLLAYLGPPEH

NEUROFIBROMIN, TYPE I NEUROFIBROMATOSIS, NF1, RAS, GAP, SIGNAL TRANSDUCTION, CANCER, GROWTH REGULATION, GTP HYDROLYSIS, PATIENT MUTATION, ARGININE FINGER, SIGNALING PROTEIN