Average structure of the interferon-binding ectodomain of the human type I interferon receptor
The human type I interferon receptor. NMR structure reveals the molecular basis of ligand binding.
The human interferon receptor: NMR-based modeling, mapping of the IFN-alpha2 binding site, and observed ligand-induced tightening
Interferon-alpha/beta receptor beta chain
IFNAR2-EC, IFN-alpha-REC, Type I interferon receptor, IFN-R, Interferon alpha/beta receptor- 2
SYDSPDYTDESCTFKISLRNFRSILSWELKNHSIVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYV TVLEGFSGNTTLFSCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKKHKPEIKG NMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESEFS
All experiments conducted in Shigemi tubes equipped with insert
Structure based upon 1947 NOE-derived distance restraints (1066 of which long range), 172 dihedral angle restraints (of which 88 experimental and 84 TALOS-derived), 138 hydrogen-bond restraints and 109 residual dipolar coupling restraints
0.4mM U-15N IFNAR2-EC; 20mM d-Tris pH 8, 0.02% NaN3
0.35mM U-13C,15N IFNAR2-EC; 20mM d-Tris pH 8, 0.02% NaN3
0.3mM U-13C,15N IFNAR2-EC; 20mM d-Tris pH 8, 0.02% NaN3
immunoglobulin fold, fibronectin fold, two-domain structure, IMMUNE SYSTEM
SYDSPDYTDESCTFKISLRNFRSILSWELKNHSIVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYV TVLEGFSGNTTLFSCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKKHKPEIKG NMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESE