Solution structure of phosphoprotein enriched in astrocytes 15 kDa (PEA-15)
Recognition of ERK MAP Kinase by PEA-15 Reveals a Common Docking Site Within the Death Domain and Death Effector Domain
PHOSPHOPROTEIN ENRICHED IN ASTROCYTES 15 kDa
MAEYGTLLQDLTNNITLEDLEQLKSACKEDIPSEKSEEITTGSAWFSFLESHNKLDKDNLSYIEHIFEISRRPDLLTMVV DYRTRVLKISEEDELDTKLTRIPSAKKYKDIIRQPSEEEIIKLAPPPKKA
structures with the least restraint violations,structures with the lowest energy
VARIOUS DOUBLE AND TRIPLE RESONANCE EXPERIMENTS
The structures are based on a total of 2937 NMR-derived restraints, including 2522 NOEs, 308 dihedral angle restraints (121 phi, 95 psi, 84 chi1 and 8 chi2) and 107 3J(NH-Ha) coupling constants
10mM sodium phosphate buffer, 1mM DTT, 50uM NaN3
DEATH EFFECTOR DOMAIN, SIX HELIX BUNDLE, APOPTOSIS