Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc
MNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTRE AISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDT AEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLR
The same protein complexed with TrkA phosphopeptide
Distance Geometry, Simulated Annealing, Molecular Dynamics, ARIA
0.5mM Shc PTB Domain, 50mM Sodium phosphate, 20mM DTT-d10, pH 6.5
Free Protein, Beta Sandwich, SIGNALING PROTEIN