Structure of dkga from E.coli at 2.13 A resolution solved by molecular replacement

Bacterial targets at IGS-CNRS, France (BIGS)

Crystal structure of Escherichia coli DkgA, a broad-specificity aldo-keto reductase.

MSYYHHHHHHLESTSLYKKAGLANPTVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGK
ALKNASVNREELFITTKLWNDDHKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYVEAWKGMIELQKEGLIKSIGVCN
FQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIR
WHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKRLGPDPDQFGG

potassium phosphate, sodium phosphate, hepes, glycerol, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K

alpha/beta-barrel, aldo-ketoreductase, NADPH dependant, Bacterial targets at IGS-CNRS, France, BIGS, Structural Genomics, OXIDOREDUCTASE

ANPTVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKNASVNREELFITTKLWNDD
HKRPREALLDSLKKLQLDYIDLYLMHWPVPAIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQI
ELHPLMQQRQLHAWNATHKIQTESWSPLAQGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAEN
FDVWDFRLDKDELGEIAKLDQGKRLGPDPDQFGG