Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-APO Structure

Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis in complex with coenzyme A and aminoglycoside substrates.

Overexpression and Mechanistic Analysis of Chromosomally Encoded Aminoglycoside 2'-N-Acetyltransferase (AAC(2')-Ic) from Mycobacterium tuberculosis

Aminosugar N-Acetyltransferase, AAC(2')-IC

MHTQVHTARLVHTADLDSETRQDIRQMVTGAFAGDFTETDWEHTLGGMHALIWHHGAIIAHAAVIQRRLIYRGNALRCGY
VEGVAVRADWRGQRLVSALLDAVEQVMRGAYQLGALSSSARARRLYASRGWLPWHGPTSVLAPTGPVRTPDDDGTVFVLP
IDISLDTSAELMCDWRAGDVW

Ammonium Sulfate, MES, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K

Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis - Complex with Coenzyme A and Tobramycin

Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis - Complex with Coenzyme A and Ribostamycin

Structure includes one nonphysiological CoA molecule bound to the exterior of the protein. This CoA is truncated to fit only the observed density.

The biological assembly is a dimer, as contained in the assymetric unit