Rat neuronal NOS heme domain with N-butyl-N'-hydroxyguanidine bound

The Novel Binding Mode of N-Alkyl-N'-Hydroxyguanidine to Neuronal Nitric Oxide Synthase Provides Mechanistic Insights into NO Biosynthesis

Crystal Structure of Constitutive Endothelial Nitric Oxide Synthase: a Paradigm for Pterin Function Involving a Novel Metal Center

NOS, type I, Neuronal NOS, N-NOS, NNOS, Constitutive NOS, NC-NOS, BNOS

RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLPSQHTRKPEDVRTKDQLFPLAKEFLDQYYSSIKRFGSKAHM
DRLEEVNKEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSA
ITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKAPRGRFDVLPLLLQANGNDPELFQIPP
ELVLEVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMDLDM
RKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNY
RLTPSFEYQPDPWNTHVWK

PEG4000, MES, ammonium acetate, pH 5.8, VAPOR DIFFUSION, SITTING DROP, temperature 280K

Rat neuronal NOS heme domain with NG-hydroxy-L-arginine bound

Rat neuronal NOS heme domain with N-isopropyl-N'-hydroxyguanidine bound

Residues 339-349 in subunit A and
339-347 in subunit B are disordered and
therefore are not included in the model.

nitric oxide synthase, oxydoreductase, heme-enzyme, OXIDOREDUCTASE