NMR STRUCTURE OF BCL-XL, AN INHIBITOR OF PROGRAMMED CELL DEATH, MINIMIZED AVERAGE STRUCTURE
X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death.
RESIDUES 1-209, LACKING THE C-TERMINAL HYDROPHOBIC REGION
MSMAMSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLD AREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVD KEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERLEHHHHHH
NMR SPECTRA WERE RECORDED ON 1-3 MM SOLUTIONS OF BCL-XL IN 20 MM SODIUM PHOSPHATE BUFFER (PH 7.3), 5 MM DTT AND 1MM EDTA AT 303K.
APOPTOSIS, PROGRAMMED CELL DEATH, BCL-2 FAMILY
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREV IPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQ VLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK