NMR structure of an AChR-peptide (Torpedo Californica, alpha-subunit residues 182-202) in complex with alpha-Bungarotoxin
The mechanism for acetylcholine receptor inhibition by alpha-neurotoxins and species-specific resistance to alpha-bungarotoxin revealed by NMR.
Acetylcholine receptor peptide (residues 206-226)
Mixing times of 40, 70 and 150 ms were measured for the NOESY experiment
distance geometry simulated annealing energy minimization
1.8 mM alpha-Bungarotoxin/AChR-peptide, buffer,pH 4
protein-protein complex, intermolecular beta sheet, bungarotoxin, acetylcholine receptor, Receptor, Toxin