Solution structure of the third helix of Antennapedia homeodomain derivatives (RQIKIWFRKWKK)
Investigation of penetratin peptides. Part 1. The environment dependent conformational properties of penetratin and two of its derivatives.
1HOM contains the whole Antennapedia homeodomain
third helix[W6F,W14F] of Antennapedia homeodomain
This sequence was synthetized in solid-phase using the Boc-chemistry. The sequence of this peptide is based on a sequence naturally found in Drosophila melanogaster (fruit fly).
This structure was determined using standard 2D homonuclear techniques.
structures with the least restraint violations,structures with the lowest energy
the structures are based on a total of 291 NOE-derived distance restraints
simulated annealing and molecular dynamics
irregular helix and multiple turn-like structure, flexibility, DNA BINDING PROTEIN