PARA-NITROPHENYL PHOSPHONOBUTANOYL D-ALANINE

Remarkable remote chiral recognition in a reaction mediated by a catalytic antibody.

DIVMTQSPLTLSVTIGQPASISCKSSQSLLYSNGKTYLNWLLQRPGQSPKRLIHLVSKLDSGVPDRITGSGSGTDFTLKI
SRVEAADLGVYYCVQGTHFPYTFGGGTKLEILRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSER
QNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC

EMQLQQSGAELLRPGTSVKLSCKTSGYIFTSYWIHWVKQRSGQGLEWIARIYPGTGSTYYNEKFKGKATLTADKSSSTAY
MQLSTLKSEDSAVYFCTRWGFIPVREDYVMDYWGQGTLVTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPV
TLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEP

PEG600, ZnSO4, Cacodylate, pH 7.00, VAPOR DIFFUSION, HANGING DROP

Structure Of A Catalytic Antibody Igg2A Fab Fragment (D2.3)

Structure Of Igg2A Fab Fragment (D2.3) Complexed With Substrate Analogue

Structure Of Igg2A Fab Fragment (D2.3) Complexed With Reaction Product

HETEROGEN
PDE IS PARA-NITROPHENYL PHOSPHONOBUTANOYL D-ALANINE
(NO2-C6H5-O-PO2-CH2-CH2-CH2-CO-NH-CH(CH3)-COOH)

SEQUENCE
THE SEQUENCES OF THE CONSTANT DOMAINS OF THE HEAVY CHAINS.
(RESIDUES H106 - H223) AND OF THE LIGHT CHAINS
(RESIDUES L107 - L214) HAVE NOT BEEN DETERMINED FOR THIS
IMMUNOGLOBULIN. THEY HAVE BEEN ASSIGNED THE CONSENSUS
SEQUENCE FOR THE CONSTANT DOMAIN OF MOUSE KAPPA LIGHT
CHAIN AND FOR THE FIRST CONSTANT DOMAIN OF MOUSE GROUP
2A HEAVY CHAINS.

ABZYME, TRANSITION STATE ANALOG, IMMUNE SYSTEM