Crystal structure of Vat(D): an acetyltransferase that inactivates streptogramin group A antibiotics.

MGPNPMKMYPIEGNKSVQFIKPILEKLENVEVGEYSYYDSKNGETFDKQILYHYPILNDKLKIGKFCSIGPGVTIIMNGA
NHRMDGSTYPFNLFGNGWEKHMPKLDQLPIKGDTIIGNDVWIGKDVVIMPGVKIGDGAIVAANSVVVKDIAPYMLAGGNP
ANEIKQRFDQDTINQLLDIKWWNWPIDIINENIDKILDNSIIREVIWKK

PEG 400, ethanol, sodium citrate, tris-HCl, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K

Crystal Structure of Vat(D) in Complex with Acetyl-CoA

The biological unit is a trimer. Chains A, B and C form a trimer.

Antibiotic resistance, acyltransferase, TRANSFERASE