Crystal structure analysis of full-length carboxyl-terminal Src kinase at 2.5 A resolution

Structure of the carboxyl-terminal Src kinase, Csk.

ROTATED-INCLINED SI(111) DOUBLE CRYSTAL MONOCHROMATOR

MSAIQASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLM
PWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDA
DGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM
TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNV
LVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVE
KGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHELHL

ammonium sulphate, HEPES buffer, pH 7.4, VAPOR DIFFUSION, SITTING DROP, temperature 288K

1BYG contains Kinase Domain Of Human C-Terminal Src Kinase Complexed With Inhibitor Staurosporine

1CSK contains human CskSH3: structural diversity near the RT-Src and n-Src loop

3LCK contains The Kinase Domain Of Human Lymphocyte Kinase, Activated Form

1AD5 contains Src Family Kinase Hck-Amp-Pnp Complex

1FMK contains Human Tyrosine-Protein Kinase C-Src

1JWO contains The Sh2 Domain Of The Csk Homologous Kinase Chk

Carboxyl-terminal Src kinase(E.C.2.7.1.112)

carboxyl-terminal Src kinase, COOH-terminal Src kinase, Csk, Src, SFK, signal transduction, SH2, SH3, Src Homology, tyrosine kinase, cytoplasmic tyrosine kinase, Cbp, oncogene, cancer, TRANSFERASE