LACK OF SYNERGY FOR INHIBITORS TARGETING A MULTI-DRUG RESISTANT HIV-1 PROTEASE

N-[2-HYDROXY-1-INDANYL]-5-[(2-TERTIARYBUTYLAMINOCARBONYL)-4(BENZO[1,3]DIOXOL-5-YLMETHYL)-PIPERAZINO]-4-HYDROXY-2-(1-PHE NYLETHYL)-PENTANAMIDE

Lack of synergy for inhibitors targeting a multi-drug-resistant HIV-1 protease.

PQITLWKRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQIPIEICGHKAIGTVLVGPT
PTNVIGRNLLTQIGCTLNF

SODIUM PHOSPHATE, SODIUM CITRATE, AMMONIUM SULPHATE, pH 6.2, VAPOR DIFFUSION, HANGING DROP, temperature 298K

INDINAVIR, INHIBITOR RECOGNITION, DRUG RESISTANCE, HIV-1 PROTEASE, HYDROLASE

FFREDLAFPQGKARKFSSEQTRANSPIRRERQVWRRDNNSLSEAGADRQGTVSFSFPQITLWQRPLVTIKIGGQLKEALL
DTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF