NMR structure of the LCCL domain and implications for DFNA9 deafness disorder.
TAPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVYGNIVYASVSSICGAAVHRGVISNSGGPVRVYSLPGRENYSSVDA NGIQSQMLSRWSASFTVTLE
This structure was determined using standard 2D homonuclear techniques
structures with the lowest energy,target function
3D-15N-separated-NOESY,3D-15N-separated-TOCSY, 1H-15N-HSQC
the structures are based on a total of 2532 restraints, 1193 are NOE-derived distance constraints, 270 dihedral angle restraints and 69 residual dipolar coupling restraints
torsion angle dynamics,simulated annealing
alpha-beta protein, STRUCTURAL GENOMICS, UNKNOWN FUNCTION
AAPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVYGNIVYASVSSICGAAVHRGVISNSGGPVRVYSLPGRENYSSVDA NGIQSQMLSRWSASFTVTKG