Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter.
1IEO sequence (synthetic) of Conus marmoreus (mollusc-hunting cone snail)
The peptide was chemically synthesized. This sequence occurs naturally in Conus tulipa (fish-hunting cone snail).
The submitted conformer models are the 20 structures with the lowest energy.
The structures are based on 213 distance restraints derived from 17 intra-residue, 93 sequential, 67 medium and 36 long range NOEs, 7 dihedral and 19 alpha H chemical shift restraints.