CRYSTAL STRUCTURE OF THE CATALYTIC SITE MUTANT S134A/H157A OF THE HUMAN CYTOMEGALOVIRUS PROTEASE

Investigating the role of histidine 157 in the catalytic activity of human cytomegalovirus protease.

MTMDEQQSQAVAPVYVGGFLARYDQSPDEAELLLPRDVVEHWLHAQGQGQPSLSVALPLNINHDDTAVVGHVAAMQSVRD
GLFCLGCVTSPRFLEIVRRASEKSELVSRGPVSPLQPDKVVEFLSGSYAGLSLASRRCDDVEQATSLSGSETTPFKAVAL
CSVGRRRGTLAVYGRDPEWVTQRFPDLTAADRDGLRAQWQRCGSTAVDASGDPFRSDSYGLLGNSVDALYIRERLPKLRY
DKQLVGVTERESYVKA

19% PEG3350, 0.1M MES 6.0, 15% GLYCEROL, 5% t-BuOH, 0.3M NaCl, VAPOR DIFFUSION, HANGING DROP, temperature 294K

CRYSTAL STRUCTURE OF THE CATALYTIC SITE MUTANT S134A OF THE HUMAN CYTOMEGALOVIRUS PROTEASE

CRYSTAL STRUCTURE OF THE H157E MUTANT OF THE HUMAN CYTOMEGALOVIRUS PROTEASE

CRYSTAL STRUCTURE OF THE H157A MUTANT OF THE HUMAN CYTOMEGALOVIRUS PROTEASE

CRYSTAL STRUCTURE OF THE H157Q MUTANT OF THE HUMAN CYTOMEGALOVIRUS PROTEASE

CONSERVED MODE OF PEPTIDOMIMETIC INHIBITION AND SUBSTRATE RECOGNITION OF HUMAN CYTOMEGALOVIRUS PROTEASE

STRUCTURE OF HUMAN CYTOMEGALOVIRUS PROTEASE

COAT PROTEIN, HYDROLASE, SERINE PROTEASE, CATALYTIC TRIAD, VIRAL PROTEASE

MTMDEQQSQAVAPVYVGGFLARYDQSPDEAELLLPRDVVEHWLHAQGQGQPSLSVALPLNINHDDTAVVGHVAAMQSVRD
GLFCLGCVTSPRFLEIVRRASEKSELVSRGPVSPLQPDKVVEFLSGSYAGLSLSSRRCDDVEAATSLSGSETTPFKHVAL
CSVGRRRGTLAVYGRDPEWVTQRFPDLTAADRDGLRAQWQRCGSTAVDASGDPFRSDSYGLLGNSVDALYIRERLPKLRY
DKQLVGVTERESYVKA