Molecular basis of the high-affinity activation of type 1 ryanodine receptors by imperatoxin A.
PEPTIDE NEUROTOXIN, RYANODINE RECEPTOR ACTIVATOR
SEQUENCE The sequence of this protein was published in a journal (Zamudio, F. Z., et al. 1997, FEBS Lett. 405, 385-389).
The peptide was chemically synthesized. This sequence occurs naturally in the venom of scorpion Pandinus imperator.
This structure was determined using standard 2D homonuclear techniques.
The submitted conformer models are those with the lowest energy and the least restraint violations.
The structures are based on a total of 519 restraints, 473 are NOE-derived distance constraints, 25 dihedral angle restraints, 12 distance restraints from hydrogen bonds, and 9 distance restraints form disulfide bonds.
Triple stranded antiparellel beta-sheet, inhibitory cystine knot, TOXIN