STRUCTURAL BASIS OF THE NHERF PDZ1-CFTR INTERACTION
Structural basis of the Na+/H+ exchanger regulatory factor PDZ1 interaction with the carboxyl-terminal region of the cystic fibrosis transmembrane conductance regulator.
Crystal Structure of the PDZ1 Domain of Human Na+/H+ Exchanger Regulatory Factor Provides Insights into the Mechanism of Carboxyl-terminal Leucine Recognition by Class I PDZ Domains
NHE-RF, A Regulatory Cofactor for NA(+)-H+ Exchange, is a Common Interactor for Merlin and ERM (MERM) Proteins
Peptide Binding Consensus of the NHE-RF-PDZ1 Domain Matches the C-terminal Sequence of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)
A C-terminal Motif Found in the Beta2-Adrenergic Receptor, P2Y1 Receptor and Cystic Fibrosis Transmembrane Conductance Regulator Determines Binding to the Na+/H+ Exchanger Regulatory Factor Family of PDZ Proteins
GMLPRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRL LVVDPEQDTRL
Sodium Acetate, Sodium Chloride, pH 4.6, VAPOR DIFFUSION, SITTING DROP, temperature 291K
1G9O contains the same protein without CFTR
Maximum Likelihood Refinement, Hydrogens have been added in the riding position, Residues from 81 to 85 refined with 2 conformations
PDZ, CFTR, NHERF, COMPLEX, SIGNALING PROTEIN
LPRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLV VDPE