THE SOLUTION STRUCTURE OF A BAY REGION 1R-BENZ[A]ANTHRACENE OXIDE ADDUCT AT THE N6 POSITION OF ADENINE OF AN OLIGODEOXYNUCLEOTIDE CONTAINING THE HUMAN N-RAS CODON 61 SEQUENCE
Intercalation of the (1R,2S,3R,4S)-N6-[1-(1,2,3,4-tetrahydro-2,3,4-trihydroxybenz[a]anthracenyl)]-2'-deoxyadenosyl adduct in the N-ras codon 61 sequence: DNA sequence effects
This structure was determined using 2D homonuclear techniques
back calculated data agree with experimental NOESY spectrum
The structure was based on a total of 485 NOE derived distance constraints.
NOE-restrained molecular dynamics/simulated annealing
1.8 mM oligodeoxynucleotide, 10 mM phosphate buffer, 0.05 mM EDTA, 0.1 M NaCl
Borgias, B.A., Thomas, P.D., Li, H., Kumar, A., and Tonelli, M.