Two different neurodegenerative diseases caused by proteins with similar structures.
Ataxia in Prion Protein (PrP)-Deficient Mice is Associated with Upregulation of the Novel PrP-like Protein Doppel
RVAENRPGAFIKQGRKLDIDFGAEGNRYYAANYWQFPDGIYYEGCSEANVTKEMLVTSCVNATQAANQAEFSREKQDSKL HQRVLWRLIKEICSAKHCDFWLERGAA
The structure was determined using triple-resonance NMR spectroscopy
structures with the least restraint violations
distance geometry molecular dynamics simulated annealing
4mM 15N or 2mM 15N/13C protein 20mM d3-NaOAc, pH5.2
mouse doppel, doppel, dpl, prion, UNKNOWN FUNCTION