SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF A CONCATEMER OF EGF-HOMOLOGY MODULES OF THE HUMAN LOW DENSITY LIPOPROTEIN RECEPTOR
NMR structure and backbone dynamics of a concatemer of epidermal growth factor homology modules of the human low-density lipoprotein receptor.
NMR Structure of a Concatemer of the First and Second Ligand-Binding Modules of the Human Low-Density Lipoprotein Receptor
An extracellular beta-propeller module predicted in lipoprotein and scavenger receptors, tyrosine kinases,epidermal growth factor precursor, and extracellular matrix components. An extracellular beta-propeller module predicted in lipoprotein and scavenger receptors, tyrosine kinases,epidermal growth factor precursor, and extracellular matrix components
GTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACK AV
1F5Y contains ligand binding modules (LB1-2) of the human LDL receptor
1LRX contains YWTD modules of the human LDL receptor
15N T1, T2, and NOE relaxations to obtain backbone dynamics information T1/T2 data were not used for structure refinement
Energy minimised average structure from 30 selected structure with lowest energy
The structures are based on: 874 NOE restraints, 64 phi dihedral angles, 14 chi1 dihedral angles, 14 hydrogen bonds, 9 calcium ion ligand restraints
1. Torsion angles dynamics 2. Restrained molecular dynamics with calcium 3. Energy minimisation
anti-parallel beta strands, calcium binding sites, LIPID BINDING PROTEIN