Human biliverdin IX beta reductase: NADP complex

NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
2'-MONOPHOSPHOADENOSINE 5'-DIPHOSPHORIBOSE

Structure of Human Biliverdin Ix Beta Reductase, an Early Fetal Bilirubin Ix Producing Enzyme

FLAVIN REDUCTASE (EC 1.6.99.1), NADPH-DEPENDENT DIAPHORASE, NADPH-FLAVIN REDUCTASE, BILIVERDIN REDUCTASE B, GREEN HEME BINDING PROTEIN

MAVKKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVVVGDVLQAADVDKTVAGQDAVIVLLGTRND
LSPTTVMSEGARNIVAAMKAHGVDKVVACTSAFLLWDPTKVPPRLQAVTDDHIRMHKVLRESGLKYVAVMPPHIGDQPLT
GAYTVTLDGRGPSRVISKHDLGHFMLRCLTTDEYDGHSTYPSHQYQ

30% PEG 3350, 0.2 M AMMONIUM SULFATE, 0.1 M SODIUM CACODYLATE PH 6.5, NADP TO ADDED TO A FINAL CONCENTRATION OF 2.5 MM

CATALYZES ELECTRON TRANSFER FROM REDUCED PYRIDINE NUCLEOTIDES TO FLAVINS AS WELL AS METHYLENE BLUE, PYRROLOQUINOLINE QUINONE, RIBOFLAVIN, OR METHEMOGLOBIN. POSSIBLE ROLE IN PROTECTING CELLS FROM OXIDATIVE DAMAGE OR IN REGULATING IRON METABOLISM. IN THE LIVER, CONVERTS BILIVERDIN TO BILIRUBIN.

THE PDB ENTRY CONTAINS AN EXTRA
N-TERMINAL METHIONINE

BILIVERDIN-IX BETA REDUCTASE, FOETAL METABOLISM, HAEM DEGRADATION, FLAVIN REDUCTASE, DIAPHORASE, GREEN HAEM BINDING PROTEIN, METHAEMOGLOBIN REDUCTASE, ALPHA/BETA DINUCLEOTIDE BINDING FOLD