Relationship of DNA structure to internal dynamics: correlation of helical parameters from NOE-based NMR solution structures of d(GCGTACGC)(2) and d(CGCTAGCG)(2) with (13)C order parameters implies conformational coupling in dinucleotide units.
Dynamics of a Bis-intercalator DNA Complex by 1H-Detected Natural Abundance 13C NMR Spectroscopy
Solution structure of a DNA complex with the fluorescent bis-intercalator TOTO determined by NMR spectroscopy.
NMR solution structure of d(CGCTAGCG)2 with TOTO
NMR solution structure of d(GCGTACGC)2 with HMT
This structure was determined using standard 2D homonuclear techniques.
back calculated data agree with experimental NOESY spectrum
The structures are based on a total of 540 restraints, 518 are NOE-derived distance constraints and 22 distance restraints from hydrogen bonds.
The RANDMARDI procedure of the complete relaxation matrix analysis method, MARDIGRAS, was used to calculate interproton distance bounds from the integrated NOESY cross-peak intensities. These distance bounds were then used as restraints in an RMD procedure to yield 20 structures.
lowest pairwise rmsd from other conformers
DNA, TOTO, C13 DYNAMICS, CONFORMATIONAL EXCHANGE, PHOSPHATE CONFORMATION, DEOXYRIBOSE CONFORMATION, HELICAL PARAMETER, ORDER PARAMETER