NMR STRUCTURE OF A 9 RESIDUE PEPTIDE FROM SMAC/DIABLO COMPLEXED TO THE BIR3 DOMAIN OF XIAP
Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.
X-LINKED INHIBITOR OF APOPTOSIS PROTEIN, XIAP
MSDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQ HAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTT
The 9 residue peptide was chemically synthesized.
1 mM protein/peptide complex, 120 mM NaCl, 1mM DTT, 10mM phosphate
zinc finger, complex, peptide-protein, apoptosis, BIR
SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQH AKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTT