CRYSTAL STRUCTURE OF P681H MUTANT OF TIR DOMAIN OF HUMAN TLR2
Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.
SRNI(CAS)YDAFVSYSERDAYWVENLMVQELENFNPPFKL(CAS)LHKRDFIHGKWIIDNIIDSIEKSHKTVFVLSENF VKSEW(CAS)KYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRF(CAS)KLRKIMNTKTYLEWPMDEAQREGFWVNLR AAIKS
SRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIHGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKY ELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAIKS
100 mM cacodylate, 10 % PEG 8000, 20 % DMSO, 200 mM MgCl2, 5 mM DTT, pH 6.8, VAPOR DIFFUSION, HANGING DROP, temperature 4K
SRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKY ELDFSHFRLFEENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAIKS