CRYSTAL STRUCTURE OF THE TIR DOMAIN OF HUMAN TLR2
Northeast Structural Genomics Consortium (NESG)
Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.
SRNI(CAS)YDAFVSYSERDAYWVENL(MSE)VQELENFNPPFKL(CAS)LHKRDFIPGKWIIDNIIDSIEKSHKTVFVL SENFVKSEW(CAS)KYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRF(CAS)KLRKI(MSE)NTKTYLEWP(MSE)D EAQREGFWVNLRAAIKS
SRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKY ELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAIKS
100 mM cacodylate, 10 % PEG 8000, 20 % DMSO, 200 mM MgCl2, 5 mM DTT, pH 6.8, VAPOR DIFFUSION, HANGING DROP, temperature 4K
Northeast Structural Genomics Consortium
beta-alpha-beta fold parallel beta sheet, Structural Genomics, PSI, Protein Structure Initiative, Northeast Structural Genomics Consortium, NESG, SIGNALING PROTEIN
SRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKY ELDFSHFRLFEENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAIKS