NMR STRUCTURE OF THE SIXTH LIGAND-BINDING MODULE OF THE LDL RECEPTOR
Three-dimensional NMR structure of the sixth ligand-binding module of the human LDL receptor: comparison of two adjacent modules with different ligand binding specificities.
1LDL contains the first ligand-binding module of the LDL receptor
1LDR contains the second ligand-binding module of the LDL receptor
Peptide synthesis - based on the human sequence
structures with the least restraint violations, structures with the lowest energy
Structures are based on 552 distance constraints, 18 backbone angle restraints and 14 sidechain angle restraints
Structure determination by Torsion angle dynamics, Molecular dynamics
3 mM LB6, 10 mM CaCl2, 1 mM 3,3,3-trimethylsilylpropionate
LDL receptor, ligand-binding domain, calcium-binding, familial hypercholesterolemia, LIPID BINDING PROTEIN