CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE PAK1

Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch.

SERINE/THREONINE-PROTEIN KINASE PAK-ALPHA

SDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRENKNPNIV
NYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDF
GFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPE
KLSAIFRDFLNRCLDMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATKNNH

Ammonium Sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 285K

Kinase domain, autoinhibitory fragment, homodimer, TRANSFERASE