One active site, two modes of reduction correlate the mechanism of leishmania pteridine reductase with pterin metabolism and antifolate drug resistance in trpanosomes

NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

Pteridine Reductase Mechanism Correlates Pterin Metabolism with Drug Resistance in Trypanosomatid Parasites.

GSHMTAPTVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPVSGA
DGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRNDEDGHEPCVGDREAMETATADLFGSNAIAPYFLIKA
FAHRVAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAV
WEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA

EXTRA GLY-SER-HIS SEQUENCE EXTENSION ON N-TERMINAL DISCREPANCIES WITH SEQUENCE IN DATA BASE AS ERROR REVEALLED IN ORIGINAL SEQUENCE

DIHYDROFOLATE REDUCTASE, PTERIDINE REDUCTASE, SHORTCHAIN DEHYDROGENASE, METHOTREXATE RESISTANCE, OXIDOREDUCTASE