STRUCTURE OF BCL-XL/BAK PEPTIDE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE
Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis.
MSMAMSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLD AREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVD KEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERLEHHHHHH
HUMAN BCL-XL, RESIDUES 1-44, 85-205, DELETION MUTANT LACKING A FLEXIBLE LOOP (RESIDUES 45-84) AND THE C-TERMINAL HYDROPHOBIC REGION, WITH A C-TERMINAL HIS-TAG
NMR SPECTRA WERE RECORDED ON 1-3 MM SOLUTIONS OF BCL-XL COMPLEXED WITH A BAK PEPTIDE IN 10 MM SODIUM PHOSPHATE BUFFER (PH 6.5) AT 303K.
APOPTOSIS, ALTERNATIVE SPLICING, COMPLEX (APOPTOSIS-PEPTIDE), COMPLEX (APOPTOSIS-PEPTIDE) complex