CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS

GNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRY
STGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYN
RDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLM
EALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKF
YTEFDRRNNRIGFALAR

HET GROUPS DMF, PHC, HII, CHA AND IP4 FORM AN INHIBITOR AND REFERRED TO AS INHIBITOR NUMBER 3 IN THE MANUSCRIPT.

ASPARTIC PROTEINASE, Aspartyl protease, Cleavage on pair of basic residues, Disease mutation, Disulfide bond, Glycoprotein, Hydrolase, Membrane, Protease, Secreted, Zymogen, HYDROLASE-HYDROLASE INHIBITOR complex