NMR STRUCTURE OF HUMAN MIP-1A D26A, MINIMIZED AVERAGE STRUCTURE
Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants.
MEAN STRUCTURE. THE STRUCTURE WAS DETERMINED USING TRIPLE-RESONANCE NMR SPECTROSCOPY ON 13C, 15N-LABELLED MIP-1A. ADDITIONAL INTERMONOMER CONSTRAINTS WERE ACQUIRED USING A MIXED 13C/15N-12C/14N SAMPLE.
REFINEMENT DETAILS CAN BE FOUND IN THE JRNL CITATION ABOVE
SIMULATED ANNEALING STARTING FROM RANDOM ATOM POSITIONS
MQVSTAALAVLLCTMALCNQFSASLAADTPTACCFSYTSRQIPQNFIADYFETSSQCSKPGVIFLTKRSRQVCADPSEEW VQKYVSDLELSA