The crystal structure of phosphoglucose isomerase-an enzyme with autocrine motility factor activity in tumor cells

The crystal structure of phosphoglucose isomerase/autocrine motility factor/neuroleukin complexed with its carbohydrate phosphate inhibitors suggests its substrate/receptor recognition

Crystallographic Structure Analysis of Glucose-6-Phosphate Isomerase at 3.5 A Resolution

MAISFDYSNALPFMQENELDYLSEFVKAAHHMLHERKGPGSDFLGWVDWPIRYDKNEFSRIKQAAERIRNHSDALVVIGI
GGSYLGARAAIEALSHTFHNQMNDTTQIYFAGQNISSTYISHLLDVLEGKDLSINVISKSGTTTEPAIAFRIFRDYMEKK
YGKEEARKRIYVTTDRTKGALKKLADQEGYETFVIPDNIGGRYSVLTAVGLLPIAVAGLNIDRMMEGAASAYHKYNNPDL
LTNESYQYAAVRNILYRKGKAIELLVNYEPSLHYVSEWWKQLFGESEGKDQKGLFPASVDFTTDLHSMGQYVQEGRRNLI
ETVLHVKKPQIELTIQEDPENIDGLNFLAGKTLDEVNKKAFQGTLLAHVDGGVPNLIVELDEMNEYTFGEMVYFFEKACG
ISGHLLGVNPFDQPGVEAYKKNMFALLGKPGFEDEKAALMKRLSK

CRYSTALS WERE GROWN BY HANGING DROP VAPOR DIFFUSION FROM 4-UL DROPLETS OF PROTEIN SOLUTION (15 MG/ML) IN 50 MM PHOSPHATE BUFFER (PH7.0) AND 0.2 M AMMONIUM PHOSPHATE AGAINST A RESERVOIR OF THE ABOVE BUFFER CONTAINING 0.4M AMMONIUM PHOSPHATE., VAPOR DIFFUSION, HANGING DROP

PHOSPHOGLUCOSE ISOMERASE, AUTOCRINEFACTOR, NEUROLEUKIN, CRYSTALLOGRAPHY MOTILITY, ISOMERASE