DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE, NMR, 21 STRUCTURES
The solution structure of the complex of Lactobacillus casei dihydrofolate reductase with methotrexate.
Crystal Structures of Escherichia Coli and Lactobacillus Casei Dihydrofolate Reductase Refined at 1.7 A Resolution. I. General Features and Binding of Methotrexate
TAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTNVVLTHQEDYQAQGAVVVHDVA AVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLAGSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQK KA
REFINEMENT DETAILS CAN BE FOUND IN THE J. MOL. BIOL. PAPER, GARGARO ET AL. CITED ABOVE.
OXIDOREDUCTASE, INHIBITOR-ENZYME COMPLEX